ULK3 (Q6PHR2) - Overview - Molecular Target Synopsis
ULK3, Serine/threonine-protein kinase ULK3
Enzyme Classification 22.214.171.124
Also Known as ULK3_HUMAN, ULK3
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. Interacts (via protein kinase domain) with SUFU.
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UniProt: ULK3 is active in the following subcellular-locations: cytoplasm.
GO terms: ULK3 is active in the following subcellular-locations: ciliary tip, cytoplasm, cytosol, membrane, phagophore assembly site.