Molecular Target Synopsis
Overview
Domains and Structures
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atat1 (Q6PH17) - Overview - Molecular Target Synopsis

Protein


atat1, Alpha-tubulin N-acetyltransferase 1
Enzyme Classification 2.3.1.108
UniProt Q6PH17

Also Known as ATAT_DANRE, atat1, mec17

Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. May be involved in neuron development. Acetylates alpha-tubulin in neurons, but not in cilia. Monomer.

4YRH
P21 ISOFORM OF MEC-17 FROM DANIO RERIO
RCSB/PDB
Inspect Structure
See all 3D Structures for atat1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
305Q6PH17-2
297Q6PH17-1

Sub-cellular localization


UniProt: atat1 is active in the following subcellular-locations: axon, cell junction, cell projection, clathrin-coated pit, cytoplasm, cytoskeleton, focal adhesion, membrane, spindle.
GO terms: atat1 is active in the following subcellular-locations: axon, clathrin-coated pit, cytoplasm, focal adhesion, microtubule, spindle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project atat1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For atat1 there are:
4 structures (7 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis