Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

PPIP5K1 (Q6PFW1) - Overview - Molecular Target Synopsis


PPIP5K1, Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Enzyme Classification
UniProt Q6PFW1

Also Known as VIP1_HUMAN, PPIP5K1, HISPPD2A, IP6K, IPS1, KIAA0377, VIP1

Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: PPIP5K1 is active in the following subcellular-locations: cell membrane, cytoplasm, cytosol.
GO terms: PPIP5K1 is active in the following subcellular-locations: cytosol, nucleoplasm, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project PPIP5K1 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC12, MDA-MB-134-VI, NCI-N87

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, HeLa-S3, NHLF

(see details)

3D Structures

At greater than 75% identity similarity to PPIP5K1 there are:
19 structures (19 chains) solved
19 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

PPIP5K1 has been screened with 3 compounds (3 bioactivities). (see details)