Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PPIP5K1 (Q6PFW1) - Overview - Molecular Target Synopsis

Protein


PPIP5K1, Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Enzyme Classification 2.7.4.21
UniProt Q6PFW1

Also Known as VIP1_HUMAN, PPIP5K1, HISPPD2A, IP6K, IPS1, KIAA0377, VIP1

Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PPIP5K1 is active in the following subcellular-locations: cell membrane, cytoplasm, cytosol.
GO terms: PPIP5K1 is active in the following subcellular-locations: cytosol, nucleoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PPIP5K1 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC12, MDA-MB-134-VI, NCI-N87

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, HeLa-S3, NHLF

(see details)

3D Structures


At greater than 75% identity similarity to PPIP5K1 there are:
19 structures (19 chains) solved
19 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PPIP5K1 has been screened with 3 compounds (3 bioactivities). (see details)