Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TRMT10B (Q6PF06) - Overview - Molecular Target Synopsis

Protein


TRMT10B, tRNA methyltransferase 10 homolog B
Enzyme Classification 2.1.1.221
UniProt Q6PF06

Also Known as TM10B_HUMAN, TRMT10B, RG9MTD3

S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: TRMT10B is active in the following subcellular-locations: cytosol, mitochondrion, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TRMT10B has gain in 2 cell-lines, loss in 5 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-134-VI, NCI-H1092, BT-549

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, NHLF

(see details)