Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

TRMT10B (Q6PF06) - Overview - Molecular Target Synopsis


TRMT10B, tRNA methyltransferase 10 homolog B
Enzyme Classification
UniProt Q6PF06

Also Known as TM10B_HUMAN, TRMT10B, RG9MTD3

S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678).

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: TRMT10B is active in the following subcellular-locations: cytosol, mitochondrion, nucleoplasm, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project TRMT10B has gain in 2 cell-lines, loss in 5 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-134-VI, NCI-H1092, BT-549

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, NHLF

(see details)