Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC27A1 (Q6PCB7) - Overview - Molecular Target Synopsis

Protein


SLC27A1, Long-chain fatty acid transport protein 1
Enzyme Classification 6.2.1.-
UniProt Q6PCB7

Also Known as S27A1_HUMAN, SLC27A1, ACSVL5, FATP1

Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane (PubMed:28178239). Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Self-associates. May function as a homodimer (By similarity). Interacts with EPRS; mediates the translocation of SLC27A1 from the cytoplasm to the plasma membrane thereby increasing the uptake of long-chain fatty acids (PubMed:28178239).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC27A1 is active in the following subcellular-locations: cell membrane, cytoplasm, endomembrane system.
GO terms: SLC27A1 is active in the following subcellular-locations: cytosol, endoplasmic reticulum, integral component of plasma membrane, membrane, mitochondrion, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC27A1 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_28, UACC_62, MDA_N

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G120, HT-144, COLO-783

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HFDPC, hMSC-AT

(see details)


Screening and Chemistry


SLC27A1 has been screened with 74 compounds (75 bioactivities), 27 compounds have bioactivities that show binding affinity of <= 500nM (28 bioactivities). (see details)