SLC27A1 (Q6PCB7) - Overview - Molecular Target Synopsis
SLC27A1, Long-chain fatty acid transport protein 1
Enzyme Classification 6.2.1.-
Also Known as S27A1_HUMAN, SLC27A1, ACSVL5, FATP1
Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane (PubMed:28178239). Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Self-associates. May function as a homodimer (By similarity). Interacts with EPRS; mediates the translocation of SLC27A1 from the cytoplasm to the plasma membrane thereby increasing the uptake of long-chain fatty acids (PubMed:28178239).
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|646||ENSG00000130304||ENST00000442725, ENST00000252595||ENSP00000413424, ENSP00000252595||Q6PCB7-1|
UniProt: SLC27A1 is active in the following subcellular-locations: cell membrane, cytoplasm, endomembrane system.
GO terms: SLC27A1 is active in the following subcellular-locations: cytosol, endoplasmic reticulum, integral component of plasma membrane, membrane, mitochondrion, plasma membrane.