Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

SLC27A1 (Q6PCB7) - Overview - Molecular Target Synopsis


SLC27A1, Long-chain fatty acid transport protein 1
Enzyme Classification 6.2.1.-
UniProt Q6PCB7

Also Known as S27A1_HUMAN, SLC27A1, ACSVL5, FATP1

Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane (PubMed:28178239). Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Self-associates. May function as a homodimer (By similarity). Interacts with EPRS; mediates the translocation of SLC27A1 from the cytoplasm to the plasma membrane thereby increasing the uptake of long-chain fatty acids (PubMed:28178239).

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: SLC27A1 is active in the following subcellular-locations: cell membrane, cytoplasm, endomembrane system.
GO terms: SLC27A1 is active in the following subcellular-locations: cytosol, endoplasmic reticulum, integral component of plasma membrane, membrane, mitochondrion, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project SLC27A1 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_MEL_28, UACC_62, MDA_N

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G120, HT-144, COLO-783

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HFDPC, hMSC-AT

(see details)

Screening and Chemistry

SLC27A1 has been screened with 74 compounds (75 bioactivities), 27 compounds have bioactivities that show binding affinity of <= 500nM (28 bioactivities). (see details)