Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABHD17C (Q6PCB6) - Overview - Molecular Target Synopsis

Protein


ABHD17C, Alpha/beta hydrolase domain-containing protein 17C
Enzyme Classification 3.1.2.22
UniProt Q6PCB6

Also Known as AB17C_HUMAN, ABHD17C, FAM108C1

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABHD17C is active in the following subcellular-locations: cell junction, cell projection, dendritic spine, postsynaptic cell membrane, postsynaptic density, recycling endosome membrane, synapse.
GO terms: ABHD17C is active in the following subcellular-locations: cell junction, dendritic spine, glutamatergic synapse, postsynaptic density, postsynaptic membrane, recycling endosome membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABHD17C has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: GTL-16, OCUM-1, SR-786

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HeLa-S3, HMEC

(see details)


Screening and Chemistry


ABHD17C has been screened with compounds ( bioactivities). (see details)