Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PKN3 (Q6P5Z2) - Overview - Molecular Target Synopsis

Protein


PKN3, Serine/threonine-protein kinase N3
Enzyme Classification 2.7.11.13
UniProt Q6P5Z2

Also Known as PKN3_HUMAN, PKN3, PKNBETA

Contributes to invasiveness in malignant prostate cancer.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
889ENSG00000160447ENST00000291906ENSP00000291906Q6P5Z2-1

Sub-cellular localization


UniProt: PKN3 is active in the following subcellular-locations: cytoplasm, nucleus, perinuclear region.
GO terms: PKN3 is active in the following subcellular-locations: Golgi apparatus, nucleus, perinuclear region of cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PKN3 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, HCT_116, NCI_ADR_RES

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NALM-6, RKO-E6, NCI-H1299

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, HeLa-S3, A549

(see details)

RNA Interference


PKN3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: OVTOKO, OHSN. (see details)

3D Structures


At greater than 50% identity similarity to PKN3 there are:
5 structures (5 chains) solved
4 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

PKN3 is solved in complex with the approved drug(s):

MI1/TOFACITINIB (4OTI_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PKN3 has been screened with compounds ( bioactivities). (see details)