Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACSM6 (Q6P461) - Overview - Molecular Target Synopsis

Protein


ACSM6, Acyl-coenzyme A synthetase ACSM6, mitochondrial
Enzyme Classification 6.2.1.2
UniProt Q6P461

Also Known as ACSM6_HUMAN, ACSM6, C10orf129

Monomer.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACSM6 is active in the following subcellular-locations: mitochondrion.
GO terms: ACSM6 is active in the following subcellular-locations: mitochondrial matrix.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACSM6 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to ACSM6 there are:
7 structures (13 chains) solved
6 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

ACSM6 is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (2VZE_A, 2VZE_B, 2VZE_C, 3EQ6_A, 3EQ6_B),
IBP/DEXIBUPROFEN (2WD9_A, 2WD9_B, 2WD9_C).

(see details)
Molecular Target 3D Synopsis