SCYL2 (Q6P3W7) - Overview - Molecular Target Synopsis
SCYL2, SCY1-like protein 2
Also Known as SCYL2_HUMAN, SCYL2, CVAK104, KIAA1360
Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine. According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system. Interacts with clathrin and AP2B1; the interaction mediates the association with the AP-2 complex.
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UniProt: SCYL2 is active in the following subcellular-locations: clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, endosome membrane, golgi apparatus, perinuclear region, trans-golgi network membrane.
GO terms: SCYL2 is active in the following subcellular-locations: clathrin-coated vesicle, endosome membrane, Golgi apparatus, perinuclear region of cytoplasm.