Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SCYL2 (Q6P3W7) - Overview - Molecular Target Synopsis

Protein


SCYL2, SCY1-like protein 2
UniProt Q6P3W7

Also Known as SCYL2_HUMAN, SCYL2, CVAK104, KIAA1360

Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine. According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system. Interacts with clathrin and AP2B1; the interaction mediates the association with the AP-2 complex.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SCYL2 is active in the following subcellular-locations: clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, endosome membrane, golgi apparatus, perinuclear region, trans-golgi network membrane.
GO terms: SCYL2 is active in the following subcellular-locations: clathrin-coated vesicle, endosome membrane, Golgi apparatus, perinuclear region of cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SCYL2 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, OVCAR_4, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KPL-4, HEL, OCI-M1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, AG445

(see details)