Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PRMT9 (Q6P2P2) - Overview - Molecular Target Synopsis

Protein


PRMT9, Protein arginine N-methyltransferase 9
Enzyme Classification 2.1.1.320
UniProt Q6P2P2

Also Known as ANM9_HUMAN, PRMT9, PRMT10

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA (PubMed:25737013, PubMed:25979344). Found in a complex with PRMT9, SF3B2 and SF3B4 (PubMed:25737013). Interacts with SF3B2 (PubMed:25737013).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PRMT9 is active in the following subcellular-locations: cytoplasm.
GO terms: PRMT9 is active in the following subcellular-locations: cytoplasm, cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PRMT9 has gain in 2 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: IGROV-1, KARPAS-422, BT-20

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: AG445, MCF-7, A549

(see details)

3D Structures


At greater than 35% identity similarity to PRMT9 there are:
66 structures (213 chains) solved
59 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PRMT9 has been screened with compounds ( bioactivities). (see details)