Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PNCK (Q6P2M8) - Overview - Molecular Target Synopsis

Protein


PNCK, Calcium/calmodulin-dependent protein kinase type 1B
Enzyme Classification 2.7.11.17
UniProt Q6P2M8

Also Known as KCC1B_HUMAN, PNCK

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PNCK is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: PNCK is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PNCK has gain in 1 cell-lines, loss in 17 cell-lines and no signal in 987 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H522, TK_10, SN12C

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1319, K-562, KMS-21BM

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH, NHLF

(see details)

RNA Interference


PNCK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: OAW42, MHM. (see details)

3D Structures


At greater than 50% identity similarity to PNCK there are:
8 structures (12 chains) solved
6 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PNCK has been screened with compounds ( bioactivities). (see details)