Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC27A4 (Q6P1M0) - Overview - Molecular Target Synopsis

Protein


SLC27A4, Long-chain fatty acid transport protein 4
Enzyme Classification 6.2.1.-
UniProt Q6P1M0

Also Known as S27A4_HUMAN, SLC27A4, ACSVL4, FATP4

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
643ENSG00000167114ENST00000300456ENSP00000300456Q6P1M0-1
237ENSG00000167114ENST00000372870ENSP00000361961Q6P1M0-2

Sub-cellular localization


UniProt: SLC27A4 is active in the following subcellular-locations: endoplasmic reticulum membrane, membrane.
GO terms: SLC27A4 is active in the following subcellular-locations: brush border membrane, endoplasmic reticulum membrane, integral component of membrane, membrane, microvillus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC27A4 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SR, MDA_N, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, CAL-12T, RKO-E6

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HeLa-S3, A549

(see details)


Screening and Chemistry


SLC27A4 has been screened with 53 compounds (53 bioactivities), 7 compounds have bioactivities that show binding affinity of <= 500nM (7 bioactivities). (see details)