Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

SLC27A4 (Q6P1M0) - Overview - Molecular Target Synopsis


SLC27A4, Long-chain fatty acid transport protein 4
Enzyme Classification 6.2.1.-
UniProt Q6P1M0

Also Known as S27A4_HUMAN, SLC27A4, ACSVL4, FATP4

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: SLC27A4 is active in the following subcellular-locations: endoplasmic reticulum membrane, membrane.
GO terms: SLC27A4 is active in the following subcellular-locations: brush border membrane, endoplasmic reticulum membrane, integral component of membrane, membrane, microvillus, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project SLC27A4 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SR, MDA_N, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, CAL-12T, RKO-E6

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HeLa-S3, A549

(see details)

Screening and Chemistry

SLC27A4 has been screened with 53 compounds (53 bioactivities), 7 compounds have bioactivities that show binding affinity of <= 500nM (7 bioactivities). (see details)