SLC27A4 (Q6P1M0) - Overview - Molecular Target Synopsis
SLC27A4, Long-chain fatty acid transport protein 4
Enzyme Classification 6.2.1.-
Also Known as S27A4_HUMAN, SLC27A4, ACSVL4, FATP4
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones.
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UniProt: SLC27A4 is active in the following subcellular-locations: endoplasmic reticulum membrane, membrane.
GO terms: SLC27A4 is active in the following subcellular-locations: brush border membrane, endoplasmic reticulum membrane, integral component of membrane, membrane, microvillus, plasma membrane.