Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAST2 (Q6P0Q8) - Overview - Molecular Target Synopsis

Protein


MAST2, Microtubule-associated serine/threonine-protein kinase 2
Enzyme Classification 2.7.11.1
UniProt Q6P0Q8

Also Known as MAST2_HUMAN, MAST2, KIAA0807, MAST205

Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation. Interacts with CDHR2.

2KYL
SOLUTION STRUCTURE OF MAST2-PDZ COMPLEXED WITH THE C-TERMINUS OF PTEN
RCSB/PDB
Inspect Structure
See all 3D Structures for MAST2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MAST2 is active in the following subcellular-locations: cell membrane, cytoplasm, cytoskeleton.
GO terms: MAST2 is active in the following subcellular-locations: cytoplasm, microtubule cytoskeleton, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MAST2 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, TK_10, PC_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SU-DHL-5, HT, HCC12

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, IMR-90

(see details)

RNA Interference


MAST2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MFM223, HCH1. (see details)

3D Structures


For MAST2 there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MAST2 has been screened with 6 compounds (6 bioactivities). (see details)