Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

H3F3C (Q6NXT2) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 08/10/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 08/10/2019)


Chains assessed2
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria2


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4Z5T_E Histone H3.3C Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 63.5 34.6 Yes No
2 empty .66 60.4 15.2 No No
3 empty 2.08 52.5 15.3 No No
4 empty 1.5 66.1 10 No No
5 empty 2.48 66.2 12.2 No No
6 empty 2.34 50.6 11.1 No No
7 empty 2.46 57.2 7.4 No No
8 empty 2.2 76.6 5 No No
9 empty 2.22 59.3 7 No No
10 empty 2.82 53.3 7.2 No No
4Z5T_A Histone H3.3C Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.88 59.3 36.1 Yes No
2 empty .67 59 15.7 No No
3 empty 2.82 65.3 20 No No
4 empty 1.6 63.4 12 No No
5 empty 1.99 74 9.8 No No
6 empty 2.53 55.2 10 No No
7 empty 2.83 65.1 8.5 No No
8 empty 2.28 55.6 11.7 No No
9 empty 2.08 54.8 8 No No
10 empty 2.34 70.1 6.6 No No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


H3F3C is involved in 13 interactions in the network.


Druggability
Overall Druggability Percentile: 30.38
Druggability for Cancer Therapeutics: 47.01
Druggability for Other Therapeutics: 39.60
Cancer-Associated
Cancer-associated percentile : 75.38
Network Articulation Point
Is H3F3C critical for communication in the network?


Detailed Graph Legend:Help