Molecular Target Synopsis
Overview
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Drugs and Clinical Candidates
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Chemistry
Ligand Efficiency Plot
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Gene Expression
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H3F3C (Q6NXT2) - Overview - Molecular Target Synopsis

Protein


H3F3C, Histone H3.3C
UniProt Q6NXT2

Also Known as H3C_HUMAN, H3F3C

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

5BWN
8 RESIDUE FRAGMENT OF
MYRISTOYL H3K9 PEPTIDE
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF SIRT3 WITH A H3K9 PEPTIDE CONTAINING A MYRISTOYL LYSINE
RCSB/PDB
Inspect Structure
See all 3D Structures for H3F3C

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
158ENSG00000188375ENST00000340398ENSP00000339835
135Q6NXT2-1

Sub-cellular localization


UniProt: H3F3C is active in the following subcellular-locations: chromosome, nucleus.
GO terms: H3F3C is active in the following subcellular-locations: nuclear euchromatin, nucleosome, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project H3F3C has gain in 15 cell-lines, loss in 2 cell-lines and no signal in 988 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H209, LN-18, NCI-H1581

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For H3F3C there are:
5 structures (6 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis