Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACSM5 (Q6NUN0) - Overview - Molecular Target Synopsis

Protein


ACSM5, Acyl-coenzyme A synthetase ACSM5, mitochondrial
Enzyme Classification 6.2.1.2
UniProt Q6NUN0

Also Known as ACSM5_HUMAN, ACSM5, MACS3

Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACSM5 is active in the following subcellular-locations: mitochondrion matrix.
GO terms: ACSM5 is active in the following subcellular-locations: mitochondrial matrix.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACSM5 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, OVCAR_4, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1011, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to ACSM5 there are:
7 structures (13 chains) solved
6 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

ACSM5 is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (2VZE_A, 2VZE_B, 2VZE_C, 3EQ6_A, 3EQ6_B),
IBP/DEXIBUPROFEN (2WD9_A, 2WD9_B, 2WD9_C).

(see details)
Molecular Target 3D Synopsis