Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LCN8 (Q6JVE9) - Overview - Molecular Target Synopsis

Protein


LCN8, Epididymal-specific lipocalin-8
UniProt Q6JVE9

Also Known as LCN8_HUMAN, LCN8, LCN5

May play a role in male fertility. May act as a retinoid carrier protein within the epididymis.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
175Q6JVE9-1
152ENSG00000204001ENST00000371688ENSP00000360753Q6JVE9-2

Sub-cellular localization


UniProt: LCN8 is active in the following subcellular-locations: secreted.
GO terms: LCN8 is active in the following subcellular-locations: extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LCN8 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: KM12, TK_10, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-LY-19, KMS-12-BM, KMS-12-PE

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)