Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LCN12 (Q6JVE5) - Overview - Molecular Target Synopsis

Protein


LCN12, Epididymal-specific lipocalin-12
UniProt Q6JVE5

Also Known as LCN12_HUMAN, LCN12

Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility. Monomer.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: LCN12 is active in the following subcellular-locations: secreted.
GO terms: LCN12 is active in the following subcellular-locations: extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LCN12 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, KM12, K_562

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-134-VI, OVKATE, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

3D Structures


At greater than 50% identity similarity to LCN12 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis