Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

STYK1 (Q6J9G0) - Overview - Molecular Target Synopsis

Protein


STYK1, Tyrosine-protein kinase STYK1
Enzyme Classification 2.7.10.2
UniProt Q6J9G0

Also Known as STYK1_HUMAN, STYK1, NOK

Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: STYK1 is active in the following subcellular-locations: membrane.
GO terms: STYK1 is active in the following subcellular-locations: extrinsic component of cytoplasmic side of plasma membrane, integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project STYK1 has gain in 5 cell-lines, loss in 4 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H322M, MCF7, KM12

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H146, A-427, COR-L88

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, A549

(see details)

RNA Interference


STYK1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: BXPC3, SCC36. (see details)

3D Structures


At greater than 35% identity similarity to STYK1 there are:
34 structures (66 chains) solved
34 are solved in complex with at least one small molecule ligand
14 are solved with an approved drug

STYK1 is solved in complex with the approved drug(s):

1N1/DASATINIB (4XEY_A, 4XEY_B),
STI/IMATINIB (1IEP_A, 1IEP_B, 1OPJ_A, 1OPJ_B, 3K5V_A, 3K5V_B, 3MS9_A, 3MS9_B, 3MSS_A, 3MSS_B, 3MSS_C, 3MSS_D, 6HD4_A, 6HD4_B, 6HD6_A, 6HD6_B),
NIL/NILOTINIB (3CS9_A, 3CS9_B, 3CS9_C, 3CS9_D, 5MO4_A),
0LI/PONATINIB (3IK3_A, 3IK3_B, 3OXZ_A),
AXI/AXITINIB (4TWP_A, 4TWP_B, 4WA9_A, 4WA9_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


STYK1 has been screened with compounds ( bioactivities). (see details)