TTBK2 (Q6IQ55) - Overview - Molecular Target Synopsis
TTBK2, Tau-tubulin kinase 2
Enzyme Classification 18.104.22.168
Also Known as TTBK2_HUMAN, TTBK2, KIAA0847
Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. Interacts with CEP164.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: TTBK2 is active in the following subcellular-locations: cell projection, centriole, centrosome, cilium, cilium basal body, cytoplasm, cytoskeleton, cytosol, microtubule organizing center, nucleus.
GO terms: TTBK2 is active in the following subcellular-locations: centriole, ciliary basal body, ciliary transition zone, cytoplasm, cytosol, extracellular space, nucleus.