Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TTBK2 (Q6IQ55) - Overview - Molecular Target Synopsis

Protein


TTBK2, Tau-tubulin kinase 2
Enzyme Classification 2.7.11.1
UniProt Q6IQ55

Also Known as TTBK2_HUMAN, TTBK2, KIAA0847

Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. Interacts with CEP164.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TTBK2 is active in the following subcellular-locations: cell projection, centriole, centrosome, cilium, cilium basal body, cytoplasm, cytoskeleton, cytosol, microtubule organizing center, nucleus.
GO terms: TTBK2 is active in the following subcellular-locations: centriole, ciliary basal body, ciliary transition zone, cytoplasm, cytosol, extracellular space, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TTBK2 has gain in 0 cell-lines, loss in 4 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CCRF_CEM, HL_60, NCI_ADR_RES

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-FI, KYSE-70, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH_RA, A549, HMEC

(see details)

RNA Interference


TTBK2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: OE19, HCH1. (see details)

3D Structures


At greater than 75% identity similarity to TTBK2 there are:
5 structures (7 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TTBK2 has been screened with compounds ( bioactivities). (see details)