Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB12 (Q6IQ22) - Overview - Molecular Target Synopsis

Protein


RAB12, Ras-related protein Rab-12
UniProt Q6IQ22

Also Known as RAB12_HUMAN, RAB12

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy. Interacts with RABIF and OPTN.

2IL1
CRYSTAL STRUCTURE OF A PREDICTED HUMAN GTPASE IN COMPLEX WITH GDP
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB12

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
244ENSG00000206418ENST00000329286ENSP00000331748Q6IQ22-1

Sub-cellular localization


UniProt: RAB12 is active in the following subcellular-locations: autophagosome, cytoplasmic vesicle, golgi apparatus membrane, lysosome membrane, recycling endosome membrane.
GO terms: RAB12 is active in the following subcellular-locations: autophagosome, cytosol, endoplasmic reticulum membrane, Golgi membrane, lysosomal membrane, lysosome, phagocytic vesicle, recycling endosome membrane, trans-Golgi network.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB12 has gain in 4 cell-lines, loss in 6 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_3, HCT_116, HOP_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1143, HCC2270, HCC38

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, NHEK

(see details)

3D Structures


For RAB12 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB12 has been screened with compounds ( bioactivities). (see details)