Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MRM1 (Q6IN84) - Overview - Molecular Target Synopsis

Protein


MRM1, rRNA methyltransferase 1, mitochondrial
Enzyme Classification 2.1.1.-
UniProt Q6IN84

Also Known as MRM1_HUMAN, MRM1

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
353ENSG00000129282ENST00000250156ENSP00000250156Q6IN84-1
155Q6IN84-2

Sub-cellular localization


UniProt: MRM1 is active in the following subcellular-locations: mitochondrion.
GO terms: MRM1 is active in the following subcellular-locations: mitochondrial matrix, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MRM1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HOP_62, A549, HCC_2998

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1581, TK, SW 480

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, K562

(see details)