Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

tmk (Q6GJI9) - Overview - Molecular Target Synopsis

Protein


tmk, Thymidylate kinase
Enzyme Classification 2.7.4.9
UniProt Q6GJI9

Also Known as KTHY_STAAR, tmk

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

4QG7
S.AUREUS TMK IN COMPLEX WITH A POTENT INHIBITOR COMPOUND 18, 2-(3- CHLOROPHENOXY)-3-METHOXY-4-{[(3S)-3-(5-METHYL-2,4-DIOXO-3,4- DIHYDROPYRIMIDIN-1(2H)-YL)PIPERIDIN-1-YL]METHYL}BENZOIC ACID
RCSB/PDB
Inspect Structure
See all 3D Structures for tmk

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Gene Copy Number Variation


In COSMIC - Cell Lines Project tmk has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For tmk there are:
8 structures (16 chains) solved
8 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis