Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

fabI (Q6GI75) - Overview - Molecular Target Synopsis

Protein


fabI, Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Enzyme Classification 1.3.1.39
UniProt Q6GI75

Also Known as FABI_STAAR, fabI

Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism. Homotetramer.

4FS3
CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS ENOYL-ACP REDUCTASE IN COMPLEX WITH NADP AND AFN-1252
RCSB/PDB
Inspect Structure
See all 3D Structures for fabI

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
256Q6GI75-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project fabI has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For fabI there are:
4 structures (8 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

fabI is solved in complex with the approved drug(s):

TCL/TRICLOSAN (3GR6_A, 3GR6_D, 3GR6_G, 3GR6_J).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


fabI has been screened with 127 compounds (183 bioactivities), 54 compounds have bioactivities that show binding affinity of <= 500nM (75 bioactivities). (see details)