Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ADAL (Q6DHV7) - Overview - Molecular Target Synopsis

Protein


ADAL, Adenosine deaminase-like protein
Enzyme Classification 3.5.4.-
UniProt Q6DHV7

Also Known as ADAL_HUMAN, ADAL

Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: ADAL is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ADAL has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MDA_N, U251, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: C32TG, CPC-N, HCC2270

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, SK-N-SH, A549

(see details)

3D Structures


At greater than 35% identity similarity to ADAL there are:
5 structures (5 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ADAL has been screened with 37 compounds (61 bioactivities). (see details)