Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

KDM4D (Q6B0I6) - Overview - Molecular Target Synopsis

Protein


KDM4D, Lysine-specific demethylase 4D
Enzyme Classification 1.14.11.-
UniProt Q6B0I6

Also Known as KDM4D_HUMAN, KDM4D, JHDM3D, JMJD2D

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

6ETV
CRYSTAL STRUCTURE OF KDM4D WITH TETRAZOLHYDRAZIDE COMPOUND 2
RCSB/PDB
Inspect Structure
See all 3D Structures for KDM4D

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
523Q6B0I6-1

Sub-cellular localization


UniProt: KDM4D is active in the following subcellular-locations: nucleus.
GO terms: KDM4D is active in the following subcellular-locations: blood microparticle, histone methyltransferase complex, nucleoplasm, nucleus, pericentric heterochromatin, site of double-strand break.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project KDM4D has gain in 4 cell-lines, loss in 1 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HM7, LN-18, DV-90

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For KDM4D there are:
274 structures (276 chains) solved
272 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

KDM4D is solved in complex with the approved drug(s):

LDP/DOPAMINE (5PHH_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


KDM4D has been screened with 52 compounds (63 bioactivities), 10 compounds have bioactivities that show binding affinity of <= 500nM (10 bioactivities). (see details)