Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PDPK2P (Q6A1A2) - Overview - Molecular Target Synopsis

Protein


PDPK2P, Putative 3-phosphoinositide-dependent protein kinase 2
Enzyme Classification 2.7.11.1
UniProt Q6A1A2

Also Known as PDPK2_HUMAN, PDPK2P, PDPK2

Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
396Q6A1A2-1

Sub-cellular localization


UniProt: PDPK2P is active in the following subcellular-locations: cytoplasm, membrane.
GO terms: PDPK2P is active in the following subcellular-locations: cytoplasm, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PDPK2P has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 90% identity similarity to PDPK2P there are:
64 structures (79 chains) solved
64 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

PDPK2P is solved in complex with the approved drug(s):

ADN/ADENOSINE (5LVN_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PDPK2P has been screened with compounds ( bioactivities). (see details)