Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

IFT81 (Q68RJ5) - Overview - Molecular Target Synopsis

Protein


IFT81, Intraflagellar transport protein 81
UniProt Q68RJ5

Also Known as IFT81_CHLRE, IFT81

Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Component of the IFT complex B, the core composed of IFT25, IFT27, IFT46, IFT52, IFT74, IFT81 and IFT88 as well as associated subunits IFT20, IFT57, IFT80 and IFT172. Interacts with IFT81; the interaction is direct: within the IFT complex B, IFT74 and IFT81 mediate the transport of tubulin within the cilium. Interacts with tubulin; interaction is direct.

4LVR
CRYSTAL STRUCTURE OF IFT81 N-TERMINAL DOMAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for IFT81

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
683Q68RJ5-1

Sub-cellular localization


UniProt: IFT81 is active in the following subcellular-locations: cell projection, cilium.
GO terms: IFT81 is active in the following subcellular-locations: apical part of cell, centrosome, cilium, intraciliary transport particle B, motile cilium.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project IFT81 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For IFT81 there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis