pam, Phenylalanine aminomutase (L-beta-phenylalanine forming)
Enzyme Classification 184.108.40.206
Also Known as
Phenylalanine aminomutase that catalyzes the rearrangement of L-phenylalanine to R-beta-phenylalanine. Catalyzes the first committed step in the biosynthesis of the side chain of the alkaloid taxol (paclitaxel), a widely-used compound with antitumor activity. Has also low phenylalanine ammonia-lyase activity and can catalyze the amination of trans-cinnamate. Homodimer (PubMed:15878763). Homotetramer, dimer of dimers (PubMed:24786474).