Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

MSL1 (Q68DK7) - Overview - Molecular Target Synopsis


MSL1, Male-specific lethal 1 homolog
UniProt Q68DK7

Also Known as MSL1_HUMAN, MSL1, MSL1L1

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation. Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3. Forms a MSL heterotetrameric core with MSL2. Interacts with KAT8 and MSL3; both interactions are direct. Directly interacts with NUPR1. Interacts with TP53BP1; this interaction may be required for MSL1 DNA repair activity, but not for histone acetyltransferase activity.

Inspect Structure
See all 3D Structures for MSL1

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: MSL1 is active in the following subcellular-locations: nucleus.
GO terms: MSL1 is active in the following subcellular-locations: MSL complex, nucleoplasm.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project MSL1 has gain in 11 cell-lines, loss in 4 cell-lines and no signal in 990 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: NCI_H522, OVCAR_5, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: UACC-893, UACC-812, KPL-4

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, K562

(see details)

3D Structures

For MSL1 there are:
3 structures (10 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis