Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAP1S (Q66K74) - Overview - Molecular Target Synopsis

Protein


MAP1S, Microtubule-associated protein 1S
UniProt Q66K74

Also Known as MAP1S_HUMAN, MAP1S, BPY2IP1, C19orf5, MAP8, VCY2IP1

Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles. Heterodimer of a heavy and a light chain. Interacts with microtubules and actin. Both MAP1S heavy and light chains interact with microtubules. MAP1S light chain interacts with actin. Interacts (via C-terminus) with GAN (via Kelch domains) (By similarity). Interacts with ESR1, LRPPRC, RASSF1 isoform A and isoform C, microtubules and VCY2. Interacts with WDR47 (via N-terminus of light chain).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MAP1S is active in the following subcellular-locations: cytoplasm, cytoskeleton, cytosol, nucleus, spindle.
GO terms: MAP1S is active in the following subcellular-locations: cell junction, cell projection, cytosol, dendrite, microtubule, microtubule associated complex, neuronal cell body, nucleolus, nucleus, perinuclear region of cytoplasm, spindle, synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MAP1S has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: UACC_62, LOXIMVI, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: PK-59, SK-N-FI, NCI-H1155

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, SK-N-SH, NHLF

(see details)


Screening and Chemistry


MAP1S has been screened with compounds ( bioactivities). (see details)