Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

METRNL (Q641Q3) - Overview - Molecular Target Synopsis

Protein


METRNL, Meteorin-like protein
UniProt Q641Q3

Also Known as METRL_HUMAN, METRNL

Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: METRNL is active in the following subcellular-locations: secreted.
GO terms: METRNL is active in the following subcellular-locations: extracellular exosome, extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project METRNL has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SF_539, MCF7, HT29

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SCC-9, SF539, G59

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, BJ, IMR-90

(see details)