Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NSUN5P2 (Q63ZY6) - Overview - Molecular Target Synopsis

Protein


NSUN5P2, Putative methyltransferase NSUN5C
Enzyme Classification 2.1.1.-
UniProt Q63ZY6

Also Known as NSN5C_HUMAN, NSUN5P2, NSUN5C, WBSCR20B, WBSCR20C

May have S-adenosyl-L-methionine-dependent methyl-transferase activity.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
315Q63ZY6-1
291Q63ZY6-6
245Q63ZY6-5
135Q63ZY6-2
117Q63ZY6-4

Sub-cellular localization


GO terms: NSUN5P2 is active in the following subcellular-locations: nucleolus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NSUN5P2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SW 1463, Hs 746T, HEY

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, NHLF

(see details)

3D Structures


At greater than 75% identity similarity to NSUN5P2 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis