Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

prs (Q63XL8) - Overview - Molecular Target Synopsis

Protein


prs, Ribose-phosphate pyrophosphokinase
Enzyme Classification 2.7.6.1
UniProt Q63XL8

Also Known as KPRS_BURPS, prs

Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). Homohexamer.

3DAH
2.3 A CRYSTAL STRUCTURE OF RIBOSE-PHOSPHATE PYROPHOSPHOKINASE FROM BURKHOLDERIA PSEUDOMALLEI
RCSB/PDB
Inspect Structure
See all 3D Structures for prs

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: prs is active in the following subcellular-locations: cytoplasm.
GO terms: prs is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project prs has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For prs there are:
1 structures (3 chains) solved
1 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

prs is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3DAH_A, 3DAH_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


prs has been screened with compounds ( bioactivities). (see details)