Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TNS2 (Q63HR2) - Overview - Molecular Target Synopsis

Protein


TNS2, Tensin-2
Enzyme Classification 3.1.3.-
UniProt Q63HR2

Also Known as TNS2_HUMAN, TNS2, KIAA1075, TENC1

Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling. Interacts with AXL. Interacts with SYK; leading to its phosphorylation (PubMed:22019427).

2LOZ
THE NOVEL BINDING MODE OF DLC1 AND TENSIN2 PTB DOMAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for TNS2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TNS2 is active in the following subcellular-locations: cell junction, cell membrane, focal adhesion.
GO terms: TNS2 is active in the following subcellular-locations: focal adhesion, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TNS2 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 695T, M059K, SUM 159PT

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HUVEC, NHLF

(see details)

3D Structures


For TNS2 there are:
5 structures (5 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis