Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Ptgs1 (Q63921) - Overview - Molecular Target Synopsis

Protein


Ptgs1, Prostaglandin G/H synthase 1
Enzyme Classification 1.14.99.1
UniProt Q63921

Also Known as PGH1_RAT, Ptgs1, Cox-1, Cox1

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. Homodimer.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
602Q63921-1

Sub-cellular localization


UniProt: Ptgs1 is active in the following subcellular-locations: endoplasmic reticulum membrane, microsome membrane.
GO terms: Ptgs1 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, nuclear envelope, organelle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Ptgs1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Screening and Chemistry


Ptgs1 has been screened with 712 compounds (925 bioactivities), 102 compounds have bioactivities that show binding affinity of <= 500nM (128 bioactivities). (see details)