Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

Ptgs1 (Q63921) - Overview - Molecular Target Synopsis


Ptgs1, Prostaglandin G/H synthase 1
Enzyme Classification
UniProt Q63921

Also Known as PGH1_RAT, Ptgs1, Cox-1, Cox1

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. Homodimer.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: Ptgs1 is active in the following subcellular-locations: endoplasmic reticulum membrane, microsome membrane.
GO terms: Ptgs1 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, nuclear envelope, organelle membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project Ptgs1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Screening and Chemistry

Ptgs1 has been screened with 712 compounds (925 bioactivities), 102 compounds have bioactivities that show binding affinity of <= 500nM (128 bioactivities). (see details)