Kcnj8 (Q63664) - Overview - Molecular Target Synopsis
Kcnj8, ATP-sensitive inward rectifier potassium channel 8
Also Known as KCNJ8_RAT, Kcnj8
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
MLARKSIIPE EYVLARIAAE NLRKPRIRDR LPKARFIAKS GACNLAHKNI
REQGRFLQDI FTTLVDLKWR HTLVIFTMSF LCSWLLFAIM WWLVAFAHGD
IYAYMEKGIT EKSGLESAVC VTNVRSFTSA FLFSIEVQVT IGFGGRMMTE
ECPLAITVLI LQNIVGLIIN AVMLGCIFMK TAQAHRRAET LIFSRHAVIA
VRNGKLCFMF RVGDLRKSMI ISASVRIQVV KKTTTPEGEV VPIHQQDIPV
DNPIESNNIF LVAPLIICHV IDKRSPLYDI SATDLVNQDL EVIVILEGVV
ETTGITTQAR TSYIAEEIQW GHRFVSIVTE EEGVYSVDYS KFGNTVRVAA
PRCSARELDE KPSILIQTLQ KSELSHQNSL RKRNSMRRNN SMRRSNSIRR
NNSSLMVPKV QFMTPEGNQC PSES
UniProt: Kcnj8 is active in the following subcellular-locations: Membrane.
GO terms: Kcnj8 is active in the following subcellular-locations: ATP-sensitive potassium channel complex, integral component of plasma membrane, intracellular membrane-bounded organelle, membrane, mitochondrion, myofibril, sarcolemma.