Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNA Interference

Kcnj8 (Q63664) - Overview - Molecular Target Synopsis


Kcnj8, ATP-sensitive inward rectifier potassium channel 8
UniProt Q63664

Also Known as KCNJ8_RAT, Kcnj8

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: Kcnj8 is active in the following subcellular-locations: Membrane.
GO terms: Kcnj8 is active in the following subcellular-locations: ATP-sensitive potassium channel complex, integral component of plasma membrane, intracellular membrane-bounded organelle, membrane, mitochondrion, myofibril, sarcolemma.

GO terms