Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNA Interference
Mutations

Kcnj8 (Q63664) - Overview - Molecular Target Synopsis

Protein


Kcnj8, ATP-sensitive inward rectifier potassium channel 8
UniProt Q63664

Also Known as KCNJ8_RAT, Kcnj8

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
424Q63664-1

Sub-cellular localization


UniProt: Kcnj8 is active in the following subcellular-locations: membrane.
GO terms: Kcnj8 is active in the following subcellular-locations: ATP-sensitive potassium channel complex, intracellular membrane-bounded organelle, membrane, mitochondrion, myofibril, sarcolemma.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Kcnj8 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

RNA Interference


Kcnj8 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)


Screening and Chemistry


Kcnj8 has been screened with compounds ( bioactivities). (see details)