Dyrk1a (Q63470) - Overview - Molecular Target Synopsis
Dyrk1a, Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Enzyme Classification 126.96.36.199
Also Known as DYR1A_RAT, Dyrk1a, Dyrk
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis. Interacts with RANBP9. Interacts with RAD54L2/ARIP4. Interacts with CRY2 (By similarity). Interacts with WDR68 (By similarity). Interacts with SRSF6 (PubMed:22767602). Interacts with SIRT1.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: Dyrk1a is active in the following subcellular-locations: nucleus speckle.
GO terms: Dyrk1a is active in the following subcellular-locations: axon, cytoplasm, cytoskeleton, dendrite, nuclear speck, nucleus, ribonucleoprotein complex.