Molecular Target Synopsis
Overview
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Camk1 (Q63450) - Overview - Molecular Target Synopsis

Protein


Camk1, Calcium/calmodulin-dependent protein kinase type 1
Enzyme Classification 2.7.11.17
UniProt Q63450

Also Known as KCC1A_RAT, Camk1

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-516', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation (By similarity). Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-275' and 'Ser-294'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. Monomer. Interacts with XPO1.

2L7L
22 RESIDUE FRAGMENT OF
CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1
IN THE STRUCTURE OF
SOLUTION STRUCTURE OF CA2+/CALMODULIN COMPLEXED WITH A PEPTIDE REPRESENTING THE CALMODULIN-BINDING DOMAIN OF CALMODULIN KINASE I
RCSB/PDB
Inspect Structure
See all 3D Structures for Camk1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
374Q63450-1

Sub-cellular localization


UniProt: Camk1 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: Camk1 is active in the following subcellular-locations: cytoplasm, cytosol, glutamatergic synapse, nucleus, postsynaptic density.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Camk1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Camk1 there are:
3 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Camk1 has been screened with compounds ( bioactivities). (see details)