Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Foxd3 (Q63245) - Overview - Molecular Target Synopsis

Protein


Foxd3, Forkhead box protein D3
UniProt Q63245

Also Known as FOXD3_RAT, Foxd3, Hfh2

Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Interacts with POU5F1.

2HDC
STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for Foxd3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
101Q63245-1

Sub-cellular localization


UniProt: Foxd3 is active in the following subcellular-locations: nucleus.
GO terms: Foxd3 is active in the following subcellular-locations: nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Foxd3 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Foxd3 there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Foxd3 has been screened with compounds ( bioactivities). (see details)