Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Gfra1 (Q62997) - Overview - Molecular Target Synopsis

Protein


Gfra1, GDNF family receptor alpha-1
UniProt Q62997

Also Known as GFRA1_RAT, Gfra1, Gdnfra, Retl1, Trnr1

Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.

4UX8
RET RECOGNITION OF GDNF-GFRALPHA1 LIGAND BY A COMPOSITE BINDING SITE PROMOTES MEMBRANE-PROXIMAL SELF-ASSOCIATION
RCSB/PDB
Inspect Structure
See all 3D Structures for Gfra1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
468Q62997-1

Sub-cellular localization


UniProt: Gfra1 is active in the following subcellular-locations: cell membrane.
GO terms: Gfra1 is active in the following subcellular-locations: anchored component of membrane, axon, external side of plasma membrane, extracellular space, neuronal cell body, plasma membrane, plasma membrane protein complex, receptor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Gfra1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Gfra1 there are:
4 structures (6 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis