Molecular Target Synopsis
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Mst1r (Q62190) - Overview - Molecular Target Synopsis



Protein


Mst1r, Macrophage-stimulating protein receptor
Enzyme Classification 2.7.10.1
UniProt Q62190

Also Known as RON_MOUSE, Mst1r, Ron, Stk

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand. Heterodimer of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates with and is negatively regulated by HYAL2. Interacts when phosphorylated with downstream effectors including PIK3R1, PCLG1, GRB2 and GAB1. Interacts with integrin beta1/ITGB1 in a ligand-independent fashion. Isoform sf-Stk forms covalent heterodimers with friend spleen focus-forming virus (FSFFV) gp55.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1378Q62190-1

Sequences


>Q62190

MGLPLPLLQS SLLLMLLLRL SAASTNLNWQ CPRIPYAASR DFSVKYVVPS 
FSAGGRVQAT AAYEDSTNSA VFVATRNHLH VLGPDLQFIE NLTTGPIGNP
GCQTCASCGP GPHGPPKDTD TLVLVMEPGL PALVSCGSTL QGRCFLHELE
PRGKALHLAA PACLFSANNN KPEACTDCVA SPLGTRVTVV EQGHASYFYV
ASSLDPELAA SFSPRSVSIR RLKSDTSGFQ PGFPSLSVLP KYLASYLIKY
VYSFHSGDFV YFLTVQPISV TSPPSALHTR LVRLNAVEPE IGDYRELVLD
CHFAPKRRRR GAPEGTQPYP VLQAAHSAPV DAKLAVELSI SEGQEVLFGV
FVTVKDGGSG MGPNSVVCAF PIYHLNILIE EGVEYCCHSS NSSSLLSRGL
DFFQTPSFCP NPPGGEASGP SSRCHYFPLM VHASFTRVDL FNGLLGSVKV
TALHVTRLGN VTVAHMGTVD GRVLQVEIAR SLNYLLYVSN FSLGSSGQPV
HRDVSRLGND LLFASGDQVF KVPIQGPGCR HFLTCWRCLR AQRFMGCGWC
GDRCDRQKEC PGSWQQDHCP PEISEFYPHS GPLRGTTRLT LCGSNFYLRP
DDVVPEGTHQ ITVGQSPCRL LPKDSSSPRP GSLKEFIQEL ECELEPLVTQ
AVGTTNISLV ITNMPAGKHF RVEGISVQEG FSFVEPVLTS IKPDFGPRAG
GTYLTLEGQS LSVGTSRAVL VNGTQCRLEQ VNEEQILCVT PPGAGTARVP
LHLQIGGAEV PGSWTFHYKE DPIVLDISPK CGYSGSHIMI HGQHLTSAWH
FTLSFHDGQS TVESRCAGQF VEQQQRRCRL PEYVVRNPQG WATGNLSVWG
DGAAGFTLPG FRFLPPPSPL RAGLVELKPE EHSVKVEYVG LGAVADCVTV
NMTVGGEVCQ HELRGDVVIC PLPPSLQLGK DGVPLQVCVD GGCHILSQVV
RSSPGRASQR ILLIALLVLI LLVAVLAVAL IFNSRRRKKQ LGAHSLSPTT
LSDINDTASG APNHEESSES RDGTSVPLLR TESIRLQDLD RMLLAEVKDV
LIPHEQVVIH TDQVIGKGHF GVVYHGEYTD GAQNQTHCAI KSLSRITEVQ
EVEAFLREGL LMRGLHHPNI LALIGIMLPP EGLPRVLLPY MRHGDLLHFI
RSPQRNPTVK DLVSFGLQVA CGMEYLAEQK FVHRDLAARN CMLDESFTVK
VADFGLARGV LDKEYYSVRQ HRHARLPVKW MALESLQTYR FTTKSDVWSF
GVLLWELLTR GAPPYPHIDP FDLSHFLAQG RRLPQPEYCP DSLYHVMLRC
WEADPAARPT FRALVLEVKQ VVASLLGDHY VQLTAAYVNV GPRAVDDGSV
PPEQVQPSPQ HCRSTSKPRP LSEPPLPT

Sub-cellular localization


UniProt: Mst1r is active in the following subcellular-locations: Membrane.
GO terms: Mst1r is active in the following subcellular-locations: cell surface, integral component of membrane, plasma membrane, stress fiber.



UniProt
GO terms