Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Melk (Q61846) - Overview - Molecular Target Synopsis

Protein


Melk, Maternal embryonic leucine zipper kinase
Enzyme Classification 2.7.11.1
UniProt Q61846

Also Known as MELK_MOUSE, Melk, Kiaa0175, Pk38

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. Monomer. Interacts with ZNF622 and PPP1R8 (By similarity).

4CQG
THE CRYSTAL STRUCTURE OF MPK38 IN COMPLEX WITH OTSSP167, AN ORALLY- ADMINISTRATIVE MELK SELECTIVE INHIBITOR
RCSB/PDB
Inspect Structure
See all 3D Structures for Melk

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
643Q61846-1

Sub-cellular localization


UniProt: Melk is active in the following subcellular-locations: cell membrane.
GO terms: Melk is active in the following subcellular-locations: cell cortex, cytoplasm, nucleus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Melk has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Melk there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Melk has been screened with compounds ( bioactivities). (see details)