Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

Il15ra (Q60819) - Overview - Molecular Target Synopsis

Protein


Il15ra, Interleukin-15 receptor subunit alpha
UniProt Q60819

Also Known as I15RA_MOUSE, Il15ra

High-affinity receptor for interleukin-15 (PubMed:17947230). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (PubMed:17947230). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (By similarity). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner. The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates (By similarity). Interacts with SYK.

2PSM
CRYSTAL STRUCTURE OF INTERLEUKIN 15 IN COMPLEX WITH INTERLEUKIN 15 RECEPTOR ALPHA
RCSB/PDB
Inspect Structure
See all 3D Structures for Il15ra

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
263Q60819-1
230Q60819-2
197Q60819-3
166Q60819-4
155Q60819-6
123Q60819-5

Sub-cellular localization


UniProt: Il15ra is active in the following subcellular-locations: cell surface, extracellular space, membrane, nucleus membrane, secreted.
GO terms: Il15ra is active in the following subcellular-locations: cell surface, cytoplasmic vesicle, extracellular space, integral component of membrane, nuclear membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Il15ra has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Il15ra there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis