Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

coaX (Q5ZX22) - Overview - Molecular Target Synopsis

Protein


coaX, Type III pantothenate kinase
Enzyme Classification 2.7.1.33
UniProt Q5ZX22

Also Known as COAX_LEGPH, coaX

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Homodimer.

3DJC
CRYSTAL STRUCTURE OF PANTOTHENATE KINASE FROM LEGIONELLA PNEUMOPHILA
RCSB/PDB
Inspect Structure
See all 3D Structures for coaX

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
256Q5ZX22-1, Q5X6J2-1

Sub-cellular localization


UniProt: coaX is active in the following subcellular-locations: cytoplasm.
GO terms: coaX is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project coaX has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For coaX there are:
1 structures (12 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis