Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

VP40 (Q5XX06) - Overview - Molecular Target Synopsis

Protein


VP40, Matrix protein VP40
UniProt Q5XX06

Also Known as VP40_EBOSU, VP40

Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. May facilitate virus budding by interacting with the nucleocapsid and the plasma membrane. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur. The hexamer form seems to be involved in budding. The octamer form binds RNA, and may play a role in genome replication. Monomer, homo-hexamer or homo-octamer. Membrane association induces conformational switch from monomer to hexamer. Interacts with host TSG101. Homo-hexamer interacts with the WW domain 3 of host NEDD4. Interacts with the nucleoprotein. May interact with VP35.

4LD8
CRYSTAL STRUCTURE OF DIMERIC SUDAN VIRUS VP40
RCSB/PDB
Inspect Structure
See all 3D Structures for VP40

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
326Q5XX06-1

Sub-cellular localization


UniProt: VP40 is active in the following subcellular-locations: host cell membrane, host endomembrane system, host late endosome membrane, virion membrane.
GO terms: VP40 is active in the following subcellular-locations: host cell endomembrane system, host cell late endosome membrane, host cell plasma membrane, virion membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project VP40 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For VP40 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis