Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

tdp2 (Q5XJA0) - Overview - Molecular Target Synopsis

Protein


tdp2, Tyrosyl-DNA phosphodiesterase 2
Enzyme Classification 3.1.4.-
UniProt Q5XJA0

Also Known as TYDP2_DANRE, tdp2, ttrap, ttrapl

DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (top2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals (By similarity). Controls gastrulation movements and left/right (L/R) axis determination via smad3-mediated regulation of cdh1/e-cadherin. Regulates the formation of Kupffer's vesicle, a signaling center essential for establishing L/R asymmetry. Modulates smad3 activity through modulating nodal-acvr1/akt4 signaling.

6CA4
CRYSTAL STRUCTURE OF HUMANIZED D. RERIO TDP2 BY 14 MUTATIONS
RCSB/PDB
Inspect Structure
See all 3D Structures for tdp2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
369Q5XJA0-1

Sub-cellular localization


UniProt: tdp2 is active in the following subcellular-locations: nucleus, pml body.
GO terms: tdp2 is active in the following subcellular-locations: cytoplasm, nucleoplasm, PML body.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project tdp2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For tdp2 there are:
3 structures (7 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


tdp2 has been screened with compounds ( bioactivities). (see details)