Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

(Q5W9R9) - Overview - Molecular Target Synopsis

Protein


, Phenylalanine 2-monooxygenase precursor
Enzyme Classification 1.13.12.9
UniProt Q5W9R9

Also Known as PAO_PSESP

Catalyzes both oxygenative decarboxylation and oxidative deamination, depending on the substrate used. Has high activity for L-Phe and L-Tyr, but relatively low activities for L-Met and L-Trp. L-Phe is mainly oxygenated and L-Met is mainly oxidized. Heterotetramer composed of 2 alpha and 2 beta subunits.

3AYL
X-RAY CRYSTAL STRUCTURES OF L-PHENYLALANINE OXIDASE (DEAMINATING AND DECABOXYLATING) FROM PSEUDOMONAS SP. P501. STRUCTURES OF THE ENZYME- LIGAND COMPLEX AND CATALYTIC MECHANISM
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
714Q5W9R9-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
6 structures (12 chains) solved
6 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

is solved in complex with the approved drug(s):

MET/METHIONINE (3AYL_A, 3AYL_B).

(see details)
Molecular Target 3D Synopsis