Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LIPJ (Q5W064) - Overview - Molecular Target Synopsis

Protein


LIPJ, Lipase member J
Enzyme Classification 3.1.1.-
UniProt Q5W064

Also Known as LIPJ_HUMAN, LIPJ, LIPL1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
366ENSG00000204022ENST00000371939ENSP00000361007Q5W064-1
154ENSG00000204022ENST00000531458ENSP00000434211

Sub-cellular localization


GO terms: LIPJ is active in the following subcellular-locations: intracellular membrane-bounded organelle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LIPJ has gain in 0 cell-lines, loss in 7 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to LIPJ there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


LIPJ has been screened with compounds ( bioactivities). (see details)