Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LIPM (Q5VYY2) - Overview - Molecular Target Synopsis

Protein


LIPM, Lipase member M
Enzyme Classification 3.1.1.-
UniProt Q5VYY2

Also Known as LIPM_HUMAN, LIPM, LIPL3

Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
423ENSG00000173239ENST00000404743ENSP00000383901Q5VYY2-1
383ENSG00000173239ENST00000539337ENSP00000440375Q5VYY2-2

Sub-cellular localization


UniProt: LIPM is active in the following subcellular-locations: secreted.
GO terms: LIPM is active in the following subcellular-locations: extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LIPM has gain in 0 cell-lines, loss in 6 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: CL-40, NCI-H209, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to LIPM there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


LIPM has been screened with compounds ( bioactivities). (see details)